How do cells respond to combinations of drugs and other signals?
Can the evolution of antibiotic resistance be predicted and prevented?
How do microbial ecosystems function?
To tackle these and related questions, we combine concepts and techniques from physics with molecular biology and advanced high-throughput techniques. Our favorite model systems are E. coli and yeast but we are broadly interested in various other biological systems. To ultimately discover the general principles and laws of biology, we use a quantitative approach, i.e. whenever possible we measure and interpret numbers rather than pictures or qualitative effects.
- New preprint on growth-mediated feedback in antibiotic responses
- New preprint splicing-mediated induction of phenotypic heterogeneity in yeast
- New paper on building ecosystem models
- New paper on biophysical modeling of drug combination effects